Anti-Ro/SSA and La/SSB antibodies

@article{Franceschini2005AntiRoSSAAL,
  title={Anti-Ro/SSA and La/SSB antibodies},
  author={Franco Franceschini and Ilaria Cavazzana},
  journal={Autoimmunity},
  year={2005},
  volume={38},
  pages={55 - 63}
}
The Ro/La system is considered as an heterogeneous antigenic complex, constituted by three different proteins (52 kDa Ro, 60 kDa Ro and La) and four small RNAs particles. Anti-Ro/SSA are the most prevalent specificity among many autoimmune diseases, such as systemic lupus erythematosus (SLE), SS/SLE overlap syndrome, subacute cutaneous LE (SCLE), neonatal lupus and primary biliary cirrhosis. In contrast, anti-La/SSB is more associated with Sjögren's syndrome (SS). The differences between 52 kDa… Expand
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