Anti-Ri-associated paraneoplastic cerebellar degeneration and breast cancer: an autopsy case study.

@article{BrievaRuz2008AntiRiassociatedPC,
  title={Anti-Ri-associated paraneoplastic cerebellar degeneration and breast cancer: an autopsy case study.},
  author={L Brieva-Ru{\'i}z and Marcos D{\'i}az-Hurtado and Xavier Mat{\'i}as-Guiu and Diego M{\'a}rquez-Medina and Jordi Tarragona and Francesc Graus},
  journal={Clinical neurology and neurosurgery},
  year={2008},
  volume={110 10},
  pages={1044-6}
}
Several antineuronal antibodies are associated with paraneoplastic cerebellar degeneration. Anti-Ri is one of these antibodies in some cases but it is more commonly associated with paraneoplastic opsoclonus myoclonus in the context of gynecological neoplasia. Anti-Ri autoantibodies are thought to be directed against onconeural antigens, NOVA-1 and NOVA-2, that are expressed by the tumor as well as by neurons. The results of the treatment of both syndromes have been disappointing, although… CONTINUE READING
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Chronic progressive paraneoplastic syndrome with prominent brainstem and spinal cord involvement, associated with type-2 anti-neuronal nuclear antibodies (ANNA-2) and breast carcinoma

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