Anti-RNP immunity: implications for tissue injury and the pathogenesis of connective tissue disease.

@article{Keith2007AntiRNPII,
  title={Anti-RNP immunity: implications for tissue injury and the pathogenesis of connective tissue disease.},
  author={Michael P. Keith and Chantal M Moratz and George C Tsokos},
  journal={Autoimmunity reviews},
  year={2007},
  volume={6 4},
  pages={
          232-6
        }
}
Certain autoantibodies are characteristic of autoimmune disease manifestations and contribute to organ pathology. The presence of high-titer antibodies to U1-RNP are associated with mixed connective tissue disease, although these antibodies may also be present in systemic lupus erythematosus and systemic sclerosis. However, the role of antibodies to U1-RNP in the pathogenesis of connective tissue disease remains unclear. Data from recent experimental studies promote the hypothesis that U1-RNP… CONTINUE READING
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