Anti-Proliferative and Pro-Apoptotic Effects of (-)-Epigallocatechin-3-Gallate Encapsulated in Chitosan Nanoparticles on Human Prostate Carcinoma Cells

  title={Anti-Proliferative and Pro-Apoptotic Effects of (-)-Epigallocatechin-3-Gallate Encapsulated in Chitosan Nanoparticles on Human Prostate Carcinoma Cells},
  author={Sameh M. Shabana and Imtiaz Ahmad Siddiqui and Naghma and Khan and Vaqar M Adhami and Qateeb Khan and Shaker and Mousa and Ahmed E. E. Hagras and Marwa El-Missiry and Hasan and Mukhtar},
(-)-epigallocatechin-3-gallate (EGCG), the major polyphenol of green tea, has shown excellent effects in preventing, as well as treating, many cancers including prostate cancer (PCa) in preclinical model systems. However its applicability to humans has met with limited success due to several issues including its limited bioavailability. We employed the use of nanotechnology to improve the outcome of cancer chemoprevention and coined the concept ‘nanochemoprevention’. Recently, we reported the… 

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  • A. DubeJ. NicolazzoI. Larson
  • Biology
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2010

Modulation of signaling pathways in prostate cancer by green tea polyphenols.

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