Anti-Parkinson botanical Mucuna pruriens prevents levodopa induced plasmid and genomic DNA damage.

@article{Tharakan2007AntiParkinsonBM,
  title={Anti-Parkinson botanical Mucuna pruriens prevents levodopa induced plasmid and genomic DNA damage.},
  author={B. D. Tharakan and Muralikrishnan Dhanasekaran and Janna Mize-Berge and Bala V. Manyam},
  journal={Phytotherapy research : PTR},
  year={2007},
  volume={21 12},
  pages={
          1124-6
        }
}
Levodopa is considered the 'gold standard' for the treatment of Parkinson's disease. However, a serious concern is dyskinesia and motor fluctuation that occurs after several years of use. In vitro experiments have shown that in the presence of divalent copper ions, levodopa may induce intense DNA damage. Mucuna pruriens cotyledon powder (MPCP) has shown anti-parkinson and neuroprotective effects in animal models of Parkinson's disease that is superior to synthetic levodopa. In the present study… CONTINUE READING
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