Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes.

@article{Wang2007AntiPEGIE,
  title={Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes.},
  author={Xinyu Wang and Tatsuhiro Ishida and Hiroshi Kiwada},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2007},
  volume={119 2},
  pages={
          236-44
        }
}
  • Xinyu Wang, T. Ishida, H. Kiwada
  • Published 1 June 2007
  • Biology, Chemistry
  • Journal of controlled release : official journal of the Controlled Release Society
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326 Citations
Highly Influential Citations
11
Background Citations
84
Methods Citations
6
Results Citations
5

326 Citations

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Citation Type

Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes.
Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats
TLDR
The present study demonstrated that the spleen is a major organ involved in the secretion of anti-PEG IgM in mice and rats, and suggests that PEGylated liposomes may function as a type-2, T-cell-independent antigen (TI-2 antigen) duringAnti-Peg IgM production.
Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon.
A hydroxyl PEG version of PEGylated liposomes and its impact on anti‐PEG IgM induction and on the accelerated clearance of PEGylated liposomes
  • Taro Shimizu, A. S. Abu Lila, T. Ishida
  • Biology, Chemistry
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2018
T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.
PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner.
Ex-vivo/in-vitro anti-polyethylene glycol (PEG) immunoglobulin M production from murine splenic B cells stimulated by PEGylated liposome.
TLDR
It is verified, both in vitro and ex vivo, that spleen cells are indeed responsible for the production of anti-PEG IgM in response to PEGylated liposomes and among the different fractions of splenic B cells, IgM-positive B Cells, rather than CD45R-positive or CD19-positive splenicB cells, are the major cells producing anti- PEG Igm in the response to stimulation by P EGylatedliposomes.
Repeated injections of PEGylated liposomal topotecan induces accelerated blood clearance phenomenon in rats.
Immune Response to PEGylated Nanomedicines: Impact of IgM Response
TLDR
PEGylation is one of the most commonly applied approaches to realize the stealthiness of the conjugated nanomaterials in the systemic circulation but strategies to avert the challenges of PEG-specific immunity are needed with a deeper understanding of the mechanism of anti-PEG immunity.
A mouse model for studying the effect of blood anti-PEG IgMs levels on the in vivo fate of PEGylated liposomes.
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References

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Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.
  • T. Ishida, M. Ichihara, H. Kiwada
  • Biology, Chemistry
    Journal of controlled release : official journal of the Controlled Release Society
  • 2006
Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice.
Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes.
Accelerated blood clearance of PEGylated liposomes upon repeated injections: effect of doxorubicin-encapsulation and high-dose first injection.
Accelerated clearance of PEGylated liposomes in rats after repeated injections.
Accelerated clearance of a second injection of PEGylated liposomes in mice.
Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats.
Repeated injections of PEG-PE liposomes generate anti-PEG antibodies.
TLDR
A study on antiliposomal properties of rabbit sera obtained after weekly injections of small liposomes containing 20% PEG-PE revealed that such antibodies could be responsible for increased phagocytosis by RES macrophages (in particular liver macrophage) and decreased circulation time.
Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection.
TLDR
The results indicate that hepatosplenic macrophages play an essential role in the enhanced clearance effect and that the change in pharmacokinetic behavior upon repeated injection is a general characteristic of liposomes, unrelated to the presence of PEG.
Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes.
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