Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas.

@article{Zeng2013AntiPD1BA,
  title={Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas.},
  author={Jing Zeng and Alfred P. See and Jillian Phallen and Christopher M. Jackson and Zineb Belcaid and Jacob Ruzevick and Nicholas M. Durham and Christian Meyer and Timothy J. Harris and Emilia Albesiano and Gustavo Pradilla and Eric Ford and John W. Wong and H Hammers and Dimitris Mathios and Betty Tyler and Henry Brem and Phuoc T Tran and Drew Mark Pardoll and Charles G. Drake and Michael S Lim},
  journal={International journal of radiation oncology, biology, physics},
  year={2013},
  volume={86 2},
  pages={343-9}
}
PURPOSE Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, and radiation is one of the main treatment modalities. However, cure rates remain low despite best available therapies. Immunotherapy is a promising modality that could work synergistically with radiation, which has been shown to increase antigen presentation and promote a proinflammatory tumor microenvironment. Programmed-death-1 (PD-1) is a surface receptor expressed on activated and exhausted T cells… CONTINUE READING
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