Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells.

@article{John2013AntiPD1AT,
  title={Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells.},
  author={Liza John and Christel Devaud and Connie P M Duong and Carmen S. M. Yong and Paul A. Beavis and Nicole M. Haynes and Melvyn T Chow and Mark J Smyth and Michael Kershaw and Phillip K Darcy},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 20},
  pages={5636-46}
}
PURPOSE To determine the antitumor efficacy and toxicity of a novel combination approach involving adoptive T-cell immunotherapy using chimeric antigen receptor (CAR) T cells with an immunomodulatory reagent for blocking immunosuppression. EXPERIMENTAL DESIGN We examined whether administration of a PD-1 blocking antibody could increase the therapeutic activity of CAR T cells against two different Her-2(+) tumors. The use of a self-antigen mouse model enabled investigation into the efficacy… CONTINUE READING
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