Anti-P-selectin antibody decreases inflammation and thrombus formation in venous thrombosis.

@article{Downing1997AntiPselectinAD,
  title={Anti-P-selectin antibody decreases inflammation and thrombus formation in venous thrombosis.},
  author={Laura J. Downing and Thomas W. Wakefield and Robert M. Strieter and Martin R. Prince and Frank J. Londy and J. Brian Fowlkes and Martial Hulin and A M Kadell and Carol A. Wilke and Scott L. Brown and Shirley K. Wrobleski and Marie D. Burdick and Donald C. Anderson and Lazar John Greenfield},
  journal={Journal of vascular surgery},
  year={1997},
  volume={25 5},
  pages={
          816-27; discussion 828
        }
}
PURPOSE Venous thrombosis and inflammation are interrelated. P-selectin contributes to activation of leukocyte-mediated inflammation. Therefore, we hypothesized that the neutralization of P-selectin would decrease vein wall inflammation and thrombosis. METHODS Twelve baboons underwent infrarenal inferior vena caval balloon occlusion to induce thrombosis. Two groups of four baboons received neutralizing intravenous anti-P-selectin antibody (PSab) GA6 or CY1748 before occlusion and at days 2… CONTINUE READING

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