Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction.

@article{Cole2008AntiMuSKPA,
  title={Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction.},
  author={Rebecca N. Cole and Stephen W Reddel and Othon L. Gervasio and William Phillips},
  journal={Annals of neurology},
  year={2008},
  volume={63 6},
  pages={
          782-9
        }
}
OBJECTIVE A subset of myasthenia gravis patients that are seronegative for anti-acetylcholine receptor (anti-AChR) antibodies are instead seropositive for antibodies against the muscle-specific kinase (anti-MuSK-positive). Here, we test whether transfer of IgG from anti-MuSK-positive patients to mice confers impairment of the neuromuscular junction and muscle weakness. METHODS IgG from anti-MuSK-positive myasthenia gravis patients or control IgG (seronegative for AChR and MuSK) was injected… CONTINUE READING
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