Anti-MUC1 antibodies react directly with MUC1 peptides presented by class I H2 and HLA molecules.

@article{Apostolopoulos1998AntiMUC1AR,
  title={Anti-MUC1 antibodies react directly with MUC1 peptides presented by class I H2 and HLA molecules.},
  author={Vasso Apostolopoulos and G. Chelvanayagam and Pei-xiang Xing and Ian F.C. Mckenzie},
  journal={Journal of immunology},
  year={1998},
  volume={161 2},
  pages={
          767-75
        }
}
Peptides bound in the groove of MHC class I molecules and detected by CTLs are not normally accessible to Ab. We now report that MUC1 peptides that are bound within the groove of MHC class I molecules (H2 and HLA) and that can be detected by CTLs can also be detected by anti-MUC1 Abs. mAbs to the middle and C-terminal regions of the class I-associated peptides but not to the N terminus were able to react with MUC1 peptides bound to H2Kb and HLA-A*0201, and only to the mid-region for H2Db, by… CONTINUE READING

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Getting into the groove: unusual features of peptide binding to MHC class I molecules and implications in vaccine design.

  • Frontiers in bioscience : a journal and virtual library
  • 2001
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