Anti-MOG autoantibodies in Italian multiple sclerosis patients: specificity, sensitivity and clinical association.

@article{Mantegazza2004AntiMOGAI,
  title={Anti-MOG autoantibodies in Italian multiple sclerosis patients: specificity, sensitivity and clinical association.},
  author={Renato Mantegazza and Piercarlo Cristaldini and P. A. Bernasconi and Fulvio Baggi and Rosetta Pedotti and Ilaria Piccini and Nerina Mascoli and Loredana La Mantia and Carlo Antozzi and Ornella Simoncini and Ferdinando Cornelio and C. Milanese},
  journal={International immunology},
  year={2004},
  volume={16 4},
  pages={559-65}
}
There is considerable evidence that multiple sclerosis (MS) is an immune-mediated disease characterized by infiltration of inflammatory cells into the CNS and demyelination. Several myelin proteins may be encephalitogenic, including myelin basic protein, proteolipid protein and myelin oligodendrocyte glycoprotein (MOG), the latter being expressed on the external layer of myelin sheaths and hence accessible to antibody attack. We investigated MOG autoreactivity in serum and cerebrospinal fluid… CONTINUE READING