Anti-LRP/LR specific antibodies and shRNAs impede amyloid beta shedding in Alzheimer's disease

@inproceedings{Jovanovi2013AntiLRPLRSA,
  title={Anti-LRP/LR specific antibodies and shRNAs impede amyloid beta shedding in Alzheimer's disease},
  author={Katarina Jovanovi{\'c} and Danielle Gonsalves and Bianca Da Costa Dias and Kiashanee Moodley and Uwe Reusch and Stefan H J Knackmuss and Clement Brian Penny and Marc S Weinberg and Melvyn Little and Stefan F T Weiss},
  booktitle={Scientific reports},
  year={2013}
}
Alzheimer's disease (AD) is the most prevalent form of dementia. The amyloid beta (Aβ) peptide is the predominant candidate aetiological agent and is generated through the sequential proteolytic cleavage of the Amyloid Precursor Protein (APP) by beta (β) and gamma (γ) secretases. Since the cellular prion protein (PrP(c)) has been shown to regulate A… CONTINUE READING

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