Anti-Inflammatory benefits of antibiotic-induced neutrophil apoptosis: tulathromycin induces caspase-3-dependent neutrophil programmed cell death and inhibits NF-kappaB signaling and CXCL8 transcription.

@article{Fischer2011AntiInflammatoryBO,
  title={Anti-Inflammatory benefits of antibiotic-induced neutrophil apoptosis: tulathromycin induces caspase-3-dependent neutrophil programmed cell death and inhibits NF-kappaB signaling and CXCL8 transcription.},
  author={Carrie D Fischer and Jennifer K Beatty and Cheryl G Zvaigzne and Douglas W. Morck and Merlyn J. Lucas and Andre G Buret},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 1},
  pages={338-48}
}
Clearance of apoptotic neutrophils is a central feature of the resolution of inflammation. Findings indicate that immuno-modulation and induction of neutrophil apoptosis by macrolide antibiotics generate anti-inflammatory benefits via mechanisms that remain obscure. Tulathromycin (TUL), a new antimicrobial agent for bovine respiratory disease, offers… CONTINUE READING