Anti-Inflammatory and Pro-apoptotic Effects of Curcumin and Resveratrol on the Human Lung Fibroblast Cell Line MRC-5

@article{Kloesch2014AntiInflammatoryAP,
  title={Anti-Inflammatory and Pro-apoptotic Effects of Curcumin and Resveratrol on the Human Lung Fibroblast Cell Line MRC-5},
  author={Burkhard Kloesch and Elisabeth Dietersdorfer and Silvia Loebsch and Guenter Steiner},
  journal={Alternative \& Integrative Medicine},
  year={2014},
  volume={2014},
  pages={1-11}
}
Background: The naturally occuring polyphenols curcumin and resveratrol are considered to be powerful antioxidants and anti-inflammatory compounds and both inhibit the proliferation of different types of cancer cells. In the present study, we investigated possible anti-inflammatory and pro-apoptotic effects of curcumin and resveratrol on the human lung fibroblast cell line MRC-5. Methods: MRC-5 cells were stimulated for 6 h with interleukin (IL)-1β or phorbol 12- myristate 13-acetate (PMA) in… 
View via Publisher
hilarispublisher.com
2 Citations
Background Citations
1

Figures from this paper

2 Citations

Antiproliferative, antimigratory, and prooxidative potential of novel platinum(IV) complexes and resveratrol on breast cancer (MDA‐MB‐231) and choriocarcinoma (JEG‐3) cell lines

Resveratrol proved to be efficient in protecting MRC‐5 cells from complex‐induced oxidative damage, while it significantly amplified antiproliferative, antimigratory, and prooxidative effects of platinum(IV) complex on both examined cancer cell lines.

Essential oil from Korean Chamaecyparis obtusa leaf ameliorates respiratory activity in Sprague-Dawley rats and exhibits protection from NF-κB-induced inflammation in WI38 fibroblast cells

Findings suggest that terpenes in essential oil from the Chamaecyparis obtusa leaf have therapeutic potential against respiratory inflammation-related disease.

36 References

Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes.

Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK Pathways

It is demonstrated that curcumin can induce the THP-1 cell apoptosis through the activation of JNK/ERK/AP1 pathways and suggested its novel use as an anti-tumor agent in acute monocytic leukemia.

Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis.

Results show that curcumin might help identify a new therapeutic pathway against hyperplasia of the synovial fibroblasts in RA.

Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts

Investigation of the anti-inflammation role of Sirt1 in NIH/3T3 fibroblast cell line and potential anti-inflammatory mechanisms of resveratrol suggest that Sirt2 is an efficient target for regulation of inflammation, providing insight on treatment of inflammation-related diseases.

Anticancer potential of curcumin: preclinical and clinical studies.

Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.

Curcumin induces pro-apoptotic endoplasmic reticulum stress in human leukemia HL-60 cells.

Inhibition of Proteasomal Function by Curcumin Induces Apoptosis through Mitochondrial Pathway*

The curcumin-induced apoptosis is mediated through the impairment of the ubiquitin-proteasome system, which targets proliferative cells more efficiently than differentiated cells and induces apoptosis via mitochondrial pathways.

Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53.

The data show that curcumin activates caspases-3 and -8 but not caspase-9, supporting the rationale that apoptosis occurs via a membrane-mediated mechanism and supporting the hypothesis thatCurcumin induces activation of a death receptor pathway.

Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells.

A general mechanism of apoptosis induction by resveratrol in ALL cells that involves a mitochondria/caspase-9-specific pathway for the activation of the caspase cascade and is independent of CD95-signaling is pointed to.

Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.

The data show that SIRT1 regulates cigarette smoke-mediated proinflammatory mediator release via NF-kappaB, implicating a role of Sirt1 in sustained inflammation and aging of the lungs.