Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-κB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-κB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated

@article{Hmlinen2007AntiInflammatoryEO,
  title={Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-$\kappa$B Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-$\kappa$B Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated},
  author={M. H{\"a}m{\"a}l{\"a}inen and R. Nieminen and P. Vuorela and M. Heinonen and E. Moilanen},
  journal={Mediators of Inflammation},
  year={2007},
  volume={2007}
}
In inflammation, bacterial products and proinflammatory cytokines induce the formation of large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS), and compounds that inhibit NO production have anti-inflammatory effects. In the present study, we systematically investigated the effects of 36 naturally occurring flavonoids and related compounds on NO production in macrophages exposed to an inflammatory stimulus (lipopolysaccharide, LPS), and evaluated the mechanisms of action… Expand
Suppression of dendritic cells' maturation and functions by daidzein, a phytoestrogen.
O-Methylated flavonol isorhamnetin prevents acute inflammation through blocking of NF-κB activation.
  • Ji Hye Yang, Sang Chan Kim, +8 authors S. Ki
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2013
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