Anti-Inflammatory Effect ofEmodin via Attenuation of NLRP3 Inflammasome Activation

  title={Anti-Inflammatory Effect ofEmodin via Attenuation of NLRP3 Inflammasome Activation},
  author={Ji-Won Han and Do-Wan Shim and Woo-Young Shin and Kang-Hyuk Heo and Su-Bin Kwak and Eun-Jeong Sim and Jae-Hyun Jeong and Tae-Bong Kang and Kwang-Ho Lee},
  booktitle={International journal of molecular sciences},
Emodin, an active constituent of oriental herbs, is widely used to treat allergy, inflammation, and other symptoms. This study provides the scientific basis for the anti-inflammasome effects of emodin on both in vitro and in vivo experimental models. Bone marrow-derived macrophages were used to study the effects of emodin on inflammasome activation by using inflammasome inducers such as ATP, nigericin, and silica crystals. The lipopolysaccharide (LPS)-induced endotoxin shock model was employed… CONTINUE READING
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