Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action.

@article{Oh2017AntiInflammatoryCS,
  title={Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action.},
  author={Kyu-Seon Oh and Heta Patel and Rachel A. Gottschalk and Wai Shing Lee and Songjoon Baek and Iain D C Fraser and Gordon L. Hager and Myong-Hee Sung},
  journal={Immunity},
  year={2017},
  volume={47 2},
  pages={
          298-309.e5
        }
}
Despite the widespread use of glucocorticoids (GCs), their anti-inflammatory effects are not understood mechanistically. Numerous investigations have examined the effects of glucocorticoid receptor (GR) activation prior to inflammatory challenges. However, clinical situations are emulated by a GC intervention initiated in the midst of rampant inflammatory responses. To characterize the effects of a late GC treatment, we profiled macrophage transcriptional and chromatinscapes with Dexamethasone… CONTINUE READING
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