Anti-Inflammatory Activity of the Methanol Extract of Moutan Cortex in LPS-Activated Raw264.7 Cells

@article{Chun2007AntiInflammatoryAO,
  title={Anti-Inflammatory Activity of the Methanol Extract of Moutan Cortex in LPS-Activated Raw264.7 Cells},
  author={Seung-Chul Chun and Seon Young Jee and Sang Gon Lee and Sook Jahr Park and Jong Rok Lee and Sang Chan Kim},
  journal={Evidence-based Complementary and Alternative Medicine : eCAM},
  year={2007},
  volume={4},
  pages={327 - 333}
}
Moutan Cortex (MCE) has been used in traditional medicine to remove heat from the blood, promote blood circulation and alleviate blood stasis. This study was conducted to evaluate the effects of MCE on regulatory mechanisms of cytokines and nitric oxide (NO) involved in immunological activity of Raw264.7 cells. Cells were pretreated with methanolic extracts of MCE, and further cultured for an appropriate time after lipopolyssacharide (LPS) addition. During the entire experimental period, 0.1… CONTINUE READING

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In these concentrations , MCE inhibited the production of NO and prostaglandin E(2 ) ( PGE(2 ) ) , the expression of inducible NO synthase ( iNOS ) , cyclooxygenase-2 ( COX-2 ) and phosphorylated inhibitor of kappa Bal pha ( p - I kappa Bal pha ) , and the activation of nuclear factor kappa B ( NF - kappa B ) .
In these concentrations , MCE inhibited the production of NO and prostaglandin E(2 ) ( PGE(2 ) ) , the expression of inducible NO synthase ( iNOS ) , cyclooxygenase-2 ( COX-2 ) and phosphorylated inhibitor of kappa Bal pha ( p - I kappa Bal pha ) , and the activation of nuclear factor kappa B ( NF - kappa B ) .
In these concentrations , MCE inhibited the production of NO and prostaglandin E(2 ) ( PGE(2 ) ) , the expression of inducible NO synthase ( iNOS ) , cyclooxygenase-2 ( COX-2 ) and phosphorylated inhibitor of kappa Bal pha ( p - I kappa Bal pha ) , and the activation of nuclear factor kappa B ( NF - kappa B ) .
In these concentrations , MCE inhibited the production of NO and prostaglandin E(2 ) ( PGE(2 ) ) , the expression of inducible NO synthase ( iNOS ) , cyclooxygenase-2 ( COX-2 ) and phosphorylated inhibitor of kappa Bal pha ( p - I kappa Bal pha ) , and the activation of nuclear factor kappa B ( NF - kappa B ) .
In these concentrations , MCE inhibited the production of NO and prostaglandin E(2 ) ( PGE(2 ) ) , the expression of inducible NO synthase ( iNOS ) , cyclooxygenase-2 ( COX-2 ) and phosphorylated inhibitor of kappa Bal pha ( p - I kappa Bal pha ) , and the activation of nuclear factor kappa B ( NF - kappa B ) .
In these concentrations , MCE inhibited the production of NO and prostaglandin E(2 ) ( PGE(2 ) ) , the expression of inducible NO synthase ( iNOS ) , cyclooxygenase-2 ( COX-2 ) and phosphorylated inhibitor of kappa Bal pha ( p - I kappa Bal pha ) , and the activation of nuclear factor kappa B ( NF - kappa B ) .
In these concentrations , MCE inhibited the production of NO and prostaglandin E(2 ) ( PGE(2 ) ) , the expression of inducible NO synthase ( iNOS ) , cyclooxygenase-2 ( COX-2 ) and phosphorylated inhibitor of kappa Bal pha ( p - I kappa Bal pha ) , and the activation of nuclear factor kappa B ( NF - kappa B ) .
In these concentrations , MCE inhibited the production of NO and prostaglandin E(2 ) ( PGE(2 ) ) , the expression of inducible NO synthase ( iNOS ) , cyclooxygenase-2 ( COX-2 ) and phosphorylated inhibitor of kappa Bal pha ( p - I kappa Bal pha ) , and the activation of nuclear factor kappa B ( NF - kappa B ) .
In these concentrations , MCE inhibited the production of NO and prostaglandin E(2 ) ( PGE(2 ) ) , the expression of inducible NO synthase ( iNOS ) , cyclooxygenase-2 ( COX-2 ) and phosphorylated inhibitor of kappa Bal pha ( p - I kappa Bal pha ) , and the activation of nuclear factor kappa B ( NF - kappa B ) .
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