Anti-Inflammatory Activity of Tanshinone IIA in LPS-Stimulated RAW264.7 Macrophages via miRNAs and TLR4–NF-κB Pathway

@article{Fan2015AntiInflammatoryAO,
  title={Anti-Inflammatory Activity of Tanshinone IIA in LPS-Stimulated RAW264.7 Macrophages via miRNAs and TLR4–NF-κB Pathway},
  author={Guanwei Fan and Xiaorui Jiang and Xiaoyan Wu and Patrick Asare Fordjour and Lin Miao and Han Zhang and Yan Zhu and Xiumei Gao},
  journal={Inflammation},
  year={2015},
  volume={39},
  pages={375-384}
}
Inflammation is a physiological response to infection or injury and involves the innate and adaptive immune system. Tanshinone IIA (Tan IIA) is a well-known flavonoid that elicits an important therapeutic effect by inhibiting inflammatory response. In this study, we examined whether Tan IIA exerts anti-inflammatory activity and investigated the possible mechanisms, including Toll-like receptor 4 (TLR4)–MyD88–nuclear factor kappa B (NF-κB) signaling pathway and microRNA expression in… CONTINUE READING
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