Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation

@article{Kaneko2006AntiInflammatoryAO,
  title={Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation},
  author={Yoshikatsu Kaneko and F. Nimmerjahn and Jeffrey V. Ravetch},
  journal={Science},
  year={2006},
  volume={313},
  pages={670 - 673}
}
Immunoglobulin G (IgG) mediates pro- and anti-inflammatory activities through the engagement of its Fc fragment (Fc) with distinct Fcg receptors (FcgRs). One class of Fc-FcgR interactions generates pro-inflammatory effects of immune complexes and cytotoxic antibodies. In contrast, therapeutic intravenous gamma globulin and its Fc fragments are anti-inflammatory. We show here that these distinct properties of the IgG Fc result from differential sialylation of the Fc core polysaccharide. IgG… 

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