Anti-Immunology: Evasion of the Host Immune System by Bacterial and Viral Pathogens
@article{Finlay2006AntiImmunologyEO, title={Anti-Immunology: Evasion of the Host Immune System by Bacterial and Viral Pathogens}, author={B. Brett Finlay and Grant McFadden}, journal={Cell}, year={2006}, volume={124}, pages={767-782} }
748 Citations
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The immune system controls the host–microbe interactions, the outcome of which can range from symbiotic coexistence with commensally microbiota, to mild asymptomatic infections, to highly virulent…
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The paper reviews some strategies used by bacteria in evading host immune system, including inhibition of complement, inhibition of cytokines, interferon or chemokines, interference with toll-like receptors, blockage of antimicrobial small molecules, and blockages of intrinsic cellular pathways.
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This review summarizes what has emerged from the current handful of studies that have addressed the direct impact of bacterial virulence factors on IS assembly in T cells and highlights potential IS-related vulnerabilities that could be exploited by these pathogens to evade T cell mediated immunity.
Brucella evasion of adaptive immunity.
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In this review, some key mechanisms that pathogenic Brucella use to evade the adaptive immune system are highlighted.
Immune Evasion, Immunopathology and the Regulation of the Immune System
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It is suggested that taking into account the co-evolutionary interactions between the host immune system and the parasitic strategies to overcome the immune response might provide a better picture of the selective pressures that shape the evolution of immune functioning.
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