Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy

@article{Horn2007AntiIgAAI,
  title={Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy},
  author={Julia Horn and V Thon and Dana Bartonkova and Ulrich Salzer and Klaus Warnatz and Michael Schlesier and H U Peter and Bodo Grimbacher},
  journal={Clinical immunology},
  year={2007},
  volume={122 2},
  pages={
          156-62
        }
}
Common Variable Immunodeficiency (CVID) patients who are seropositive for anti-IgA antibodies have a predisposition for anaphylactoid reactions to intravenous immunoglobulin replacement therapy (IVIG). Among 88 CVID patients, we identified eight with IgG anti-IgA antibodies (9%). All eight completely lacked IgA (<0.0009 g/l). Five of them had a history of anaphylactoid reactions to IVIG. However, four of these five patients tolerated subcutaneous immunoglobulin replacement therapy (SCIG). To… CONTINUE READING
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