Anti-IL-4 treatment prevents dermal collagen deposition in the tight-skin mouse model of scleroderma.

Abstract

The tight-skin (Tsk/+) mutant mouse, a putative murine model of scleroderma, is characterized primarily by the excessive deposition of collagen and other extracellular matrix molecules in the dermis, and also by a developmentally acquired defect in pulmonary architecture. Passive transfer experiments have suggested an etiologic role for the immune system in… (More)

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@article{Ong1998AntiIL4TP, title={Anti-IL-4 treatment prevents dermal collagen deposition in the tight-skin mouse model of scleroderma.}, author={Christopher Ong and Carol Wong and Charles R Roberts and Hung Sia Teh and Frank Robert Jirik}, journal={European journal of immunology}, year={1998}, volume={28 9}, pages={2619-29} }