Anti-IFN-γ autoantibodies are strongly associated with HLA-DR*15:02/16:02 and HLA-DQ*05:01/05:02 across Southeast Asia.

@article{Ku2016AntiIFNAA,
  title={Anti-IFN-γ autoantibodies are strongly associated with HLA-DR*15:02/16:02 and HLA-DQ*05:01/05:02 across Southeast Asia.},
  author={Cheng-Lung Ku and Chia-Hao Lin and Su-Wei Chang and C C Chu and Jasper Fuk-Woo Chan and Xiao-fei Kong and Chen-Hsiang Lee and Emily A Rosen and Jing-Ya Ding and W Lee and Jacinta Bustamante and Torsten Witte and Han-Po Shih and C. Y. Kuo and Ploenchan Chetchotisakd and Sasisopin Kiertiburanakul and Yupin Suputtamongkol and Kwok - Yung Yuen and Jean Casanova and Steven M Holland and Rainer Doffinger and Sarah K. Browne and Chih-Yu Chi},
  journal={The Journal of allergy and clinical immunology},
  year={2016},
  volume={137 3},
  pages={945-8.e8}
}
examined, suggesting that the absence of functional T cells, rather than specifically CD247, affects NKdifferentiation. This observation is consistent with data from patients undergoing stem cell transplantation (SCT) in whom the first NK cells to repopulate the periphery have an immature phenotype and are less able to mediate cytotoxicity before T-cell recovery. Interestingly, the ability of peripheral blood NK cells from the CD247-deficient patient to proliferate in mixed lymphocyte cultures… CONTINUE READING

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