Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients.

@article{Graus2001AntiHuassociatedPE,
  title={Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients.},
  author={Francesc Graus and Florence Keime-Guibert and Ram{\'o}n Re{\~n}{\'e} and Baya Benyahia and Teresa Ribalta and Carlos Ascaso and Ge{\`o}rgia Escaram{\'i}s and Jean-Yves Delattre},
  journal={Brain : a journal of neurology},
  year={2001},
  volume={124 Pt 6},
  pages={
          1138-48
        }
}
We reviewed 200 patients with paraneoplastic encephalomyelitis (PEM) and anti-Hu antibodies to show possible clinical differences with respect to previous series, and to identify patient, tumour and treatment-related characteristics associated with neurological disability and survival. The median age of the 200 patients was 63 years (range 28-82 years) and 75% were men. The predominant neurological syndromes were sensory neuropathy (54%), cerebellar ataxia (10%), limbic encephalitis (9%) and… 
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
A patient positive for anti-Hu antibodies who developed a sensory neuropathy and Holmes–Adie syndrome is reported, who was a nonsmoker and had no relevant past or family history.
Paraneoplastic limbic encephalitis associated with lung cancer
TLDR
The results suggest patients with GABAB encephalitis might respond better to immunotherapy than the classical PLE patients with anti-Hu antibodies, and Lung cancer patients with PLE might have better outcome due to earlier diagnosis and prompt anti-cancer treatment.
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TLDR
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Paraneoplastic cerebellar degeneration associated with antineuronal antibodies: analysis of 50 patients.
TLDR
The relative frequency of the antineuronal antibodies associated with PCD is examined, the neurological symptoms and signs, associated tumours, disability and survival between groups of PCD with different antibodies are compared and patient-, tumour- and treatment-related characteristics are attempted.
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References

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TLDR
Patients with rapidly developing sensory neuropathy or symptoms of encephalomyelitis should be studied for the presence of the anti-Hu antibody; if the antibody is found, the possibility of small-cell lung cancer should be investigated.
Limbic encephalitis and small cell lung cancer. Clinical and immunological features.
TLDR
Patients with LE and SCLC who are without anti-Hu antibodies are less likely to develop PEM and seem to improve more often after treatment of the cancer than those who present anti- Hu antibodies.
Utility of anti‐Hu antibodies in the diagnosis of paraneoplastic sensory neuropathy
TLDR
It is emphasized that in patients with possible PSN, the absence of Hu‐Abs does not exclude cancer, particularly in those patients with risk factors for SCLC.
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TLDR
Treatment with IVIg at the doses given in the present protocol was not effective in paraneoplastic CNS syndromes associated with antineuronal antibodies.
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TLDR
Five patients with PSN, high titers of anti-Hu antibodies (type 1 antineuronal nuclear autoantibodies), and an indolent clinical course are described; one patient had small-cell or undifferentiated large-cell lung cancer.
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TLDR
The efficacy of PE with other immunosuppressive therapies in the stabilization of the neurologic deficit is uncertain and it is concluded that the patients with a stable course started the treatment when the neurological deficit was not severe.
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TLDR
Seropositivity for ANNA-1 can expedite the diagnosis and treatment of otherwise occult cancer in patients, especially tobacco abusers, with varied neurologic and gastroenterologic presentations.
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TLDR
The neurologic presentation was limited to moderate sensitive neuropathy associated with two complex partial seizures without any further signs of limbic encephalopathy, and a paraneoplastic etiology should be considered in patients with moderate symptomatology.
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TLDR
Complete response of the tumor seems to have a favorable influence on the course of paraneoplastic encephalomyelitis (PEM).
Epilepsia partialis continua: A new manifestation of anti‐Hu–associated paraneoplastic encephalomyelitis
TLDR
The possibility of an anti‐Hu–associated paraneoplastic disorder must be considered in patients with cortical encephalitis presenting with EPC when a brain tumor can be excluded.
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