Anti-Her2 single-chain antibody mediated DNMTs-siRNA delivery for targeted breast cancer therapy.

@article{Dou2012AntiHer2SA,
  title={Anti-Her2 single-chain antibody mediated DNMTs-siRNA delivery for targeted breast cancer therapy.},
  author={Shuang Dou and Yan-dan Yao and Xianzhu Yang and Tian-meng Sun and Cheng-qiong Mao and Erwei Song and Jun R. Wang},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={161 3},
  pages={875-83}
}
The targeted delivery of small interfering RNA (siRNA) to specific tumor tissues and tumor cells remains as one of the key challenges in the development of RNA interference as a therapeutic application. To target breast cancer, we developed a therapeutic delivery system using a fusion protein of an anti-Her2 single-chain antibody fragment with a positively charged protamine, namely F5-P, as the carrier to specifically deliver siRNA-targeting DNA methyltransferases 1 and/or 3b genes (siDNMTs… CONTINUE READING
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