Anti-HLA class I antibody binding to airway epithelial cells induces production of fibrogenic growth factors and apoptotic cell death: a possible mechanism for bronchiolitis obliterans syndrome.

@article{Jaramillo2003AntiHLACI,
  title={Anti-HLA class I antibody binding to airway epithelial cells induces production of fibrogenic growth factors and apoptotic cell death: a possible mechanism for bronchiolitis obliterans syndrome.},
  author={Andr{\'e}s David Ram{\'i}rez Jaramillo and Craig R Smith and Takahiro Maruyama and Leiying Zhang and G. Alexander Patterson and Thalachallour Mohanakumar},
  journal={Human immunology},
  year={2003},
  volume={64 5},
  pages={521-9}
}
Development of anti-HLA class I antibodies is associated with bronchiolitis obliterans syndrome (BOS) after lung transplantation. BOS is characterized histologically by significant fibrosis and airway epithelial cell (AEC) apoptosis. Thus, this study was designed to determine whether anti-HLA class I antibodies can activate AECs to produce growth factors and to undergo apoptosis. KCC-266 AECs were activated with the W6/32 anti-HLA class I monoclonal antibody. Proliferation and apoptosis levels… CONTINUE READING

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