Anti-HIV siamycin I directly inhibits autophosphorylation activity of the bacterial FsrC quorum sensor and other ATP-dependent enzyme activities.

@article{Ma2011AntiHIVSI,
  title={Anti-HIV siamycin I directly inhibits autophosphorylation activity of the bacterial FsrC quorum sensor and other ATP-dependent enzyme activities.},
  author={Pikyee Ma and Kenzo Nishiguchi and Hayley M Yuille and Lianne M Davis and Jiro 5 Nakayama and Mary K Phillips-Jones},
  journal={FEBS letters},
  year={2011},
  volume={585 17},
  pages={2660-4}
}
Siamycin I disrupts growth and quorum sensing in Enterococcus faecalis. Using purified intact protein, we demonstrate here that quorum membrane sensor kinase FsrC is a direct target of siamycin I, reducing pheromone-stimulated autophosphorylation activity by up to 91%. Inhibition was non-competitive with ATP as substrate. Other ATP-binding enzymes were also inhibited, including nine other membrane sensor kinases of E. faecalis, Rhodobacter sphaeroides PrrB, porcine Na(+)-dependent ATPase and… CONTINUE READING
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