Anti-HIV activity of defective cyanovirin-N mutants is restored by dimerization.

Abstract

Cyanovirin-N (CV-N) is a two-domain, cyanobacterial protein that inhibits human immunodeficiency virus (HIV) at nanomolar concentrations by binding to high mannose sugars on the HIV envelope glycoprotein gp120. The wild type protein can exist as a monomer or a domain-swapped dimer with the monomer and dimer containing two or four sugar binding sites… (More)
DOI: 10.1074/jbc.M109.094938

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