Anti-HIV-1 and cytotoxicity of a new dimeric thiazepine alkaloid isolated from Ixora undulata Roxb. leaves

The crude alkaloidal extract of Ixora undulata Roxb. leaves recorded a cytotoxicity of IC50 = 125 µg/mL against EL4 and revealed a reduction with CC50 = 47 µg/mL in the viability of MT-4 cells, beside a 50% protection with EC50 > 47 µg/mL against HIV-1IIIB. Bioassay guided fractionation of the crude alkaloidal extract of I. undulata leaves led to the… (More)