Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1alpha (SDF-1alpha) and SDF-1beta are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage.

@article{Shioda1998AntiHIV1AC,
  title={Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1alpha (SDF-1alpha) and SDF-1beta are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage.},
  author={Tatsuo Shioda and Hisashi Kato and Yukano Ohnishi and K. Tashiro and Masaya Ikegawa and Emi E. Nakayama and Huajun Hu and Atsushi Kato and Yuko T. Sakai and H Liu and T. Honjo and Akio Nomoto and Aikichi Iwamoto and Chikao Morimoto and Yoshiyuki Nagai},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 11},
  pages={6331-6}
}
CD26 is a leukocyte-activation antigen that is expressed on T lymphocytes and macrophages and possesses dipeptidyl peptidase IV (DPPIV) activity, whose natural substrates have not been identified yet. CXC chemokines, stromal cell-derived factor 1alpha (SDF-1alpha) and 1beta (SDF-1beta), sharing the receptor CXCR-4, are highly efficacious chemoattractants… CONTINUE READING