Anti-HIV-1 activity of trichobitacin, a novel ribosome-inactivating protein.

  title={Anti-HIV-1 activity of trichobitacin, a novel ribosome-inactivating protein.},
  author={Yong-Tang Zheng and K L Ben and Sook Won Jin},
  journal={Acta pharmacologica Sinica},
  volume={21 2},
AIM To determine whether trichobitacin, a novel ribosome-inactivating protein purified from the root tubers of Trichosanthes kirilowii, possesses the anti-HIV activity. METHODS The inhibition of syncytial cell formation induced by human immunodeficiency virus type 1 (HIV-1) was determined under microscope, reduction of HIV-1 p24 antigen expression level was measured by ELISA, and decrease in numbers of HIV-1 antigen positive cells in acutely and chronically infected cultures were detected by… CONTINUE READING

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