Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine.

  title={Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine.},
  author={Edinete M Silva and Cl{\'a}udio C{\'e}sar Cirne-Santos and Izabel Christina de Palmer Paix{\~a}o Frugulhetti and Bernardo Galv{\~a}o-Castro and Elvira Maria Breier Saraiva and Martin E. Kuehne and Dumith Chequer Bou-Habib},
  journal={Planta medica},
  volume={70 9},
The Iboga alkaloid congener 18-methoxycoronaridine (18-MC) exhibits in vitro leishmanicidal and in vivo anti-addiction properties. In this paper, we describe that 18-MC inhibits HIV-1 infection in human peripheral blood mononuclear cells (PBMCs) and monocyte-derived macrophages. We found that 18-MC inhibits the replication of primary isolates of HIV-1 in a dose-dependent manner, regardless of the preferential chemokine receptor usage of the isolates, at non-cell-toxic concentrations. The… CONTINUE READING