Anti-GaL IgG antibodies in sera of newborn humans and baboons and its significance in pig xenotransplantation.

@article{Minanov1997AntiGaLIA,
  title={Anti-GaL IgG antibodies in sera of newborn humans and baboons and its significance in pig xenotransplantation.},
  author={Oktavijan P. Minanov and Silviu Itescu and Francisca A Neethling and A S Morgenthau and Peter Kwiatkowski and David K C Cooper and Robert E. Michler},
  journal={Transplantation},
  year={1997},
  volume={63 2},
  pages={182-6}
}
We have previously demonstrated that hyperacute rejection does not occur in a pig-to-newborn baboon heart transplant model, presumably because of low levels of cytotoxic antipig antibodies present in the serum of newborn baboons. Cytotoxic antipig antibodies are primarily directed to alpha-1,3-galactosyl (alpha Gal) residues on endothelial cell surface… CONTINUE READING