Anti-GBM nephritis in the mouse: severe proteinuria in the heterologous phase

  title={Anti-GBM nephritis in the mouse: severe proteinuria in the heterologous phase},
  author={Karel J. M. Assmann and Martina M. Tangelder and Will P. J. Lange and Gideon Schrijver and Robert A. P. Koene},
  journal={Virchows Archiv A},
Highly reproducible anti glomerular basement membrane (GBM) nephritis has been induced in the mouse after a single injection of rabbit or goat antibody against purified homologous GBM. The severity of albuminuria was closely related to the amount of antibody given. With doses of 4 mg or more, low serum albumin concentrations, sometimes accompanied by ascites and oedema, were observed after 1 week. Glomerular injury was characterized by an initial accumulation of polymorphonuclear granulocytes… CONTINUE READING
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Terminal complement pathway in heterologous anti-GBM nephritis in rabbits

  • GC Groggel, DJ Salant, HG Rennke, WG Couser
  • Kidney Int
  • 1984
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