Anti-GAD Monoclonal Antibody Delays the Onset of Diabetes Mellitus in NOD Mice

Abstract

Insulin Dependent Diabetes Mellitus (IDDM type I) is the result of autoimmune destruction of insulin producing pancreatic β-cells by the cellular immune system, specifically, autoreactive T cells. Disease progression is evident by multiple autoantibodies responding to self-antigens in a cascade mechanism, wherein the first self-antigen induces the… (More)
DOI: 10.1023/A:1018939900961

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