Anti-Fas on nonhematopoietic tumors: levels of Fas/APO-1 and bcl-2 are not predictive of biological responsiveness.

@article{OwenSchaub1994AntiFasON,
  title={Anti-Fas on nonhematopoietic tumors: levels of Fas/APO-1 and bcl-2 are not predictive of biological responsiveness.},
  author={Laurie B. Owen-Schaub and Robert R Radinsky and Ewa Kruzel and Karen Berry and Shin Yonehara},
  journal={Cancer research},
  year={1994},
  volume={54 6},
  pages={1580-6}
}
Fas/APO-1 is a cell surface protein known to trigger apoptosis in a variety of cell types upon specific antibody binding. Although extensively studied on normal and malignant hematopoietic cells, little is known about Fas/APO-1 on nonhematopoietic cells. In the study presented here, we have examined Fas/APO-1 expression and function on 11 human tumors of… CONTINUE READING