Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway.

@article{Faouzi2001AntiFasIH,
  title={Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway.},
  author={Saadia Faouzi and Bernhard Burckhardt and Jennifer C Hanson and Carson B. Campe and Laura W. Schrum and Richard A. Rippe and Jacquelyn J. Maher},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 52},
  pages={49077-82}
}
Agonistic antibodies against the Fas receptor, when administered to mice in vivo, cause significant apoptosis in the liver. In this study we show that anti-Fas antibody not only causes apoptosis of liver cells but also provokes hepatic inflammation. Two hours after injection of anti-Fas, when mice displayed evidence of caspase-3 activation and apoptosis, we found significant hepatic induction of the CXC chemokines macrophage inflammatory protein-2 and KC. Coincident with the chemokine induction… CONTINUE READING

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Anti-Fas Induces Inflammation

  • F. Dallegri, L. Ottonello
  • Inflamm. Res
  • 1997

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