Corpus ID: 212554081

Anti-Edema Effect of Epigallocatechin against Acute Spinal Cord Injury in Rats and its Correlation with the P38MAPK/NF-κb Signaling Pathway

@inproceedings{Tao2017AntiEdemaEO,
  title={Anti-Edema Effect of Epigallocatechin against Acute Spinal Cord Injury in Rats and its Correlation with the P38MAPK/NF-$\kappa$b Signaling Pathway},
  author={Lin Tao and Yue Zhu},
  year={2017}
}
Spinal cord injury (SCI) is a serious health problem with high care costs and involves primary and secondary mechanisms of injury. SCI destroys the local nerve tissues at the injured site by mechanical trauma. The secondary injury can destroy neighbouring nerve tissue that is not involved in the primary injury [1]. The mechanism associated with secondary injury include edema, altered blood flow and changes in microvascular permeability [2], the secondary injury is the main reason for functional… Expand

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References

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TLDR
The experimental findings indicated that GB can protect rats against acute SCI, and that its underlying mechanism may be related to the inhibition of JAK/STAT signaling pathway activation, improvement of the Bcl-2/Bax ratio, decreased caspase-3 gene and protein expression and further inhibition of secondary cell apoptosis following SCI. Expand
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