Anti-ERBB2 sh-RNA Suppress Both Cell Growth and Tumor Growth in ERBB2-Overexpressing Upper Gastrointestinal Adenocarcinomas

Abstract

ERBB2 is overexpressed in 15–25% of upper gastrointestinal adenocarcinomas. We use a stable lentiviral shRNA model to demonstrate that ERBB2 suppression in upper gastrointestinal adenocarcinomas with documented ERBB2 amplification effectively decreases ERBB2 protein levels and decreases cell viability. Further, we evaluate tumor growth of cells treated with… (More)
DOI: 10.1007/s11605-009-0957-9

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@article{Arrington2009AntiERBB2SS, title={Anti-ERBB2 sh-RNA Suppress Both Cell Growth and Tumor Growth in ERBB2-Overexpressing Upper Gastrointestinal Adenocarcinomas}, author={Amanda Kathleen Arrington and Julia O Davydova and Selwyn Maurice Vickers and Masato Yamamoto}, journal={Journal of Gastrointestinal Surgery}, year={2009}, volume={13}, pages={1754-1761} }