Anti-DNA antibody idiotypes in systemic lupus erythematosus.

  title={Anti-DNA antibody idiotypes in systemic lupus erythematosus.},
  author={David Alan Isenberg and Yehuda Shoenfeld and Michael Madaio and Joyce Rauch and Morris Reichlin and Bernard David Stollar and Robert S. Schwartz},
  volume={2 8400},
Monoclonal anti-DNA antibodies prepared by the hybridoma technique were used for an analysis of idiotypes of anti-DNA antibodies in systemic lupus erythematosus (SLE). Serum levels of one idiotypic marker, 16/6/R, were higher than normal in 40 of 74 patients (54%) with active SLE, compared with only 6 of 24 patients (25%) with inactive SLE, 9 of 38 patients (25%) with rheumatoid arthritis, and 4 of 96 normal subjects (4%). Levels of the 16/6/R idiotypic marker were determined in serially… CONTINUE READING

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