Anti-DNA antibodies: a diagnostic and prognostic tool for systemic lupus erythematosus?

@article{Riboldi2005AntiDNAAA,
  title={Anti-DNA antibodies: a diagnostic and prognostic tool for systemic lupus erythematosus?},
  author={Piersandro Riboldi and Maria Gerosa and Gabriella Moroni and Antonella Radice and Flavio Allegri and Alberto Renato Sinico and Angela Tincani and Pier Luigi Meroni},
  journal={Autoimmunity},
  year={2005},
  volume={38 1},
  pages={39-45}
}
The clinical impact of anti-DNA antibodies lies on their diagnostic power for systemic lupus erythematosus (SLE), being a formal classification criterion. In spite of such a disease association, low-avidity anti-DNA antibodies might also be part of the natural autoantibody repertoire. Their switch to pathogenic high-avidity autoantibodies is the result of the autoimmune process leading to SLE.Anti-DNA antibodies were shown to play a role in SLE pathogenesis and particularly in kidney damage… CONTINUE READING

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