Anti-DNA and autoantibodies.

  title={Anti-DNA and autoantibodies.},
  author={David S. Pisetsky},
  journal={Current opinion in rheumatology},
  volume={12 5},
Systemic lupus erythematosus is a prototypic autoimmune disease characterized by antinuclear antibodies (ANAs), including pathogenic specificities to DNA. As shown by recent research, ANA production is a genetically determined process in which self antigens drive B and T cells that have escaped the normal mechanisms of tolerance. Although antibodies can… CONTINUE READING