Anti-DFS70 antibodies detected by immunoblot methods: A reliable tool to confirm the dense fine speckles ANA pattern.

@article{Bizzaro2016AntiDFS70AD,
  title={Anti-DFS70 antibodies detected by immunoblot methods: A reliable tool to confirm the dense fine speckles ANA pattern.},
  author={Nicola Bizzaro and Fiorenza Pesente and Francesco Cucchiaro and Maria Giaele Infantino and Marilina Tampoia and Danilo Villalta and Martina Fabris and Elio Tonutti},
  journal={Journal of immunological methods},
  year={2016},
  volume={436},
  pages={50-3}
}
BACKGROUND Autoantibodies to the DFS70 (dense fine speckles 70) protein have been identified among the antinuclear antibodies (ANA) in patients with various disorders. However, the ANA test in indirect immunofluorescence (IIF) is not a reliable method to identify anti-DFS70 antibodies. We undertook this study to evaluate the diagnostic performance of two new immunoblot methods for the detection of anti-DFS70 antibodies and to investigate whether their different DFS70 antigen composition could… CONTINUE READING