Anti-Candida activity of cispentacin: the active transport by amino acid permeases and possible mechanisms of action.

@article{Capobianco1993AntiCandidaAO,
  title={Anti-Candida activity of cispentacin: the active transport by amino acid permeases and possible mechanisms of action.},
  author={John O Capobianco and Dorothy Zakula and M L Coen and Rucker C. Johnson Goldman},
  journal={Biochemical and biophysical research communications},
  year={1993},
  volume={190 3},
  pages={1037-44}
}
Cispentacin tranport into Candida albicans CCH442 was via a specific inducible proline permease and other amino acid permeases. Drug entry was also dependent upon the proton motive force. The apparent Km and Vmax for drug uptake under induced conditions were 0.4 mM and 7 nmol/microliter/min, respectively, with cellular accumulation in the mM range. Cispentacin uptake was competitively inhibited by L-proline with an apparent Ki of 75 microM. Cispentacin did not charge to transfer-RNA or… CONTINUE READING

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