Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response.

@article{Tseng2013AntiCD47AP,
  title={Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response.},
  author={Diane Tseng and Jens-Peter Volkmer and Stephen B. Willingham and Humberto Contreras-Trujillo and John W. Fathman and Nathaniel B. Fernhoff and Jun Seita and Matthew A Inlay and Kipp Weiskopf and Masanori Miyanishi and Irving L Weissman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 27},
  pages={11103-8}
}
Mobilization of the T-cell response against cancer has the potential to achieve long-lasting cures. However, it is not known how to harness antigen-presenting cells optimally to achieve an effective antitumor T-cell response. In this study, we show that anti-CD47 antibody-mediated phagocytosis of cancer by macrophages can initiate an antitumor T-cell immune… CONTINUE READING