Anti-CD40 antibody enhances responses to polysaccharide without mimicking T cell help.

@article{Vinuesa1999AntiCD40AE,
  title={Anti-CD40 antibody enhances responses to polysaccharide without mimicking T cell help.},
  author={C Garc{\'i}a de Vinuesa and I. C. M. Maclennan and Mary Holman and Gerry G. B. Klaus},
  journal={European journal of immunology},
  year={1999},
  volume={29 10},
  pages={3216-24}
}
Protection against infection with encapsulated bacteria is mediated by IgG antibodies against the capsular polysaccharides. Production of such antibodies is impaired during infancy, when susceptibility to bacterial meningitis is greatest. Recent studies have proposed the use of anti-CD40 antibody to increase responsivenesses to polysaccharide antigens. We show here that the IgG response to a model polysaccharide antigen is greatly increased, but retains thymus-independent characteristics… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…