Anti-CD4 abrogates rejection and reestablishes long-term tolerance to syngeneic newborn hearts grafted in mice chronically infected with Trypanosoma cruzi

@article{Santos1992AntiCD4AR,
  title={Anti-CD4 abrogates rejection and reestablishes long-term tolerance to syngeneic newborn hearts grafted in mice chronically infected with Trypanosoma cruzi},
  author={Ricardo Ribeiro dos Santos and Marcos Ant{\^o}nio Rossi and Jos{\'e} Luis Laus and Jo{\~a}o Francisco Santos Silva and Wilson Savino and Jeff Mengel},
  journal={The Journal of Experimental Medicine},
  year={1992},
  volume={175},
  pages={29 - 39}
}
The contribution of autoimmunity in the genesis of chronic Chagas' heart pathology is not clear. In the present study, we show that: (a) BALB/c mice chronically infected with Trypanosoma cruzi reject syngeneic newborn hearts; (b) in vivo treatment with anti-CD4 but not anti-CD8 monoclonal antibodies (mAbs) abrogates rejection; (c) CD4+ T cells from chronically infected mice proliferate in vitro to syngeneic myocardium antigens and induce heart graft destruction when injected in situ; (d) anti… CONTINUE READING

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