Anti-CD30 antibody conjugated liposomal doxorubicin with significantly improved therapeutic efficacy against anaplastic large cell lymphoma.

@article{Molavi2013AntiCD30AC,
  title={Anti-CD30 antibody conjugated liposomal doxorubicin with significantly improved therapeutic efficacy against anaplastic large cell lymphoma.},
  author={Ommoleila Molavi and Xiao-bing Xiong and Donna Douglas and Norm M. Kneteman and Satoshi Nagata and Ira Pastan and Quincy S-C Chu and Afsaneh Lavasanifar and Raymond Lai},
  journal={Biomaterials},
  year={2013},
  volume={34 34},
  pages={8718-8725}
}
The use of nano-carriers has been shown to improve the delivery and efficacy of chemotherapeutic agents in cancer patients. Recent studies suggest that decoration of the surface of nano-carriers with various targeting moieties may further improve the overall therapeutic efficacy. In this study, we compared the therapeutic efficacy of Doxil(®) (commercial doxorubicin-loaded liposomes) and that of Doxil(®) conjugated with anti-CD30 antibodies (CD30-targeted Doxil(®)) in treating anaplastic large… CONTINUE READING

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